Vice President, Translational (Oncology)
Location: Watertown, MA
In This Role You’ll Be Responsible For:
• Lead the Translational Medicine function within Clinical Development reporting to the CMO and manage teams in both clinical and preclinical functions.
• Develop translational strategies and foster key relationships across in-house teams to successfully support translational efforts on an expanding pipeline of discovery and clinical stage programs.
• Lead and further build key dimensions of Translational Biology & Translational Medicine and integrate functions with the Research and Discovery teams to develop compounds and accompanying biomarker decision points.
• Manage Director level FTEs and their reporting teams and help mentor and provide career growth in support of their functions.
• Lead the Translational Medicine group and provide strategic oversight and tactical support for preclinical and clinical translational studies.
• Provide vision and direction for growth of the group with regards to hiring plans, critical assay design, biomarker and patient stratification planning.
• Facilitate productive collaboration and integration within the R&D, Clinical Development, and Quality/Regulatory colleagues.
• Drive the discovery and adoption of innovative pharmacodynamic and patient selection assays within the organization.
• Contribute to the preclinical evaluation of disease indications for clinical pipeline programs and early discovery programs for go/no-go decision making.
• Ensure staffing and processes are in place to enable adherence to timelines for critical preclinical and clinical translational deliverables, including data acquisition and analysis/interpretation.
• Maintain clear and consistent communication and alignment on translational medicine deliverables with senior management and BOD.
• Spearhead and manage key external presentations on translational data, including congresses, publications, and at both investor and business development meetings.
• Demonstrate leadership within the Targeted Protein Degradation space through forums and interactions with external peers and translational medicine groups in the space.
• Provide direction and oversight for budgeting, including medium- and long-range planning.
In This Role You’ll Bring With You:
• PhD or MD/PhD with 10+ years experience in the pharma/biotech industry, including at least 5+ years experience in both clinical and preclinical translational medicine leadership function.
• Disease area expertise in oncology is a must and/or inflammation/immunology is highly desirable.
• Proven track record of developing and successfully implementing translational pharmacodynamic (PD) and patient selection assays in Phase I/Phase II clinical trials.
• A track record of seeing Translational efforts through preclinical to Phase II stage activities through examples in past career accomplishments.
• Proven track record of productive preclinical collaborations involving in vitro systems as well as in vivo disease models for selection/validation of disease indications.
• Demonstrated ability to build a translational medicine function and manage the team and budget demands.
• Strong interpersonal skills and proven ability to work cross-functionally with diverse Clinical and Research/Discovery functions and peers to foster relationships as well as with key management and board of director colleagues.
• Strong communication skills, including track record of publications, presentations, and key written contributions to regulatory documents including biomarker plans, briefing documents, IND and NDA submissions.
• Proven ability to establish extensive and productive networks of clinical and preclinical translational experts and leverage those relationships to remain on top of current advances in the field of Oncology and Targeted Protein Degradation.
• Ability to adapt to demands of an evolving clinical stage biotech with amazing peers, funding, and driven leaders.