T-Cell Scientist

Our Cell Therapy client in Houston, TX is growing and looking to add a T-Cell Scientist I/II to their team! The Discovery Scientist will design and perform experiments for the development of next generation TCR-engineered T-cell therapies against solid cancers. Investigation will focus on in vitro human cell-based immunoassays. The position will play a critical role in the evaluation and identification of lead next generation technologies for clinical evaluation. The successful candidate will demonstrate excellent oral and written communication skills, work well independently and as part of a team, and be able to work on multiple projects simultaneously. Broad expertise in human cellular immunology, tumor immunology, genetic modification of primary human lymphocytes, and flow cytometry is essential for this role. The position is primarily a hands-on laboratory-based role with associated downstream document work from data analysis and presentations to contributing to regulatory or IP-related document submissions.  Responsibilities include but not limited to: 

 

  • Work with team members, with possible interaction with third-party contract research organizations (CROs) to conduct next generation studies to advance the TCR-T cell platform for the company.
  • Design and perform in vitro studies assessing next generation technology in the TCR-T cell field
  • Collate and analyze experimental data; as well as, preparation of study reports
  • Summarize results and communicate in-progress experiment updates to team members
  • Learn and utilize electronic lab notebook software to maintain experiment records
  • Preparation of abstracts, posters and presentations; as well as, present scientific findings at conferences
  • May assist with scope of work development for CRO-conducted in vivo studies
  • Assist in authoring SOPs and study protocols for methods and studies performed within laboratory and those which may be conducted by CROs
  • Prepare manuscripts from study data and contribute to the preparation of regulatory and intellectual property documentation
  • Manufacture lead candidate TCR-T cells for subsequent coordination and transfer to CROs for the purpose of in vivo testing in xenogeneic tumor models

Requirements: 

  • PhD in immunology or a closely related field. An equivalent combination of education and experience may be considered (e.g., a B.Sc. with 5+ years or a M.Sc. with 2+ years of experience in the field and/or in industry).
  • Significant hands-on experience manufacturing and testing genetically engineered human T-cells is required. Additionally, hands-on experience with flow cytometer operation and flow data analysis is required.
  • Expertise in the manipulation, manufacture, characterization, and ex vivo expansion of primary human T cells
  • Detailed knowledge of cellular and/or tumor immunology principles (including T-cell biology and TCR histocompatability restriction) and technologies, and relevant experimental techniques (e.g., cell culture, T-cell activation protocols, flow cytometry, in vitro cellular assays, etc.)
  • Experience with genetic engineering techniques and immunology-oriented practices and assays/analytical methods:
    • meticulous cell culture technique, with proficiency in working with primary human lymphocytes;
    • molecular biology techniques (plasmid/vector design with experience in related design software, cloning and PCR technologies, and genetic manipulation);
    • multi-parameter flow cytometry (>7 colors) and proficiency in FACS data analysis programs;
    • genetic manipulation of T cells using non-viral or viral methods;
    • cell separation technologies (e.g., bead-based and FACS); and, immunology-based in vitro cellular functional and characterization assays (e.g., tumor cell killing, cytokine production, signaling pathway activation, gene expression, cell proliferation, etc.)
  • Experience in design, implementation and completion of discovery and/or translational research studies