Our client is an early stage oncology therapeutics start-up led by successful serial entrepreneur and they have $75+ million in funding! As they scale their research efforts, they're looking for an experienced crystallographer to lead their Structural Biology efforts. You will be working with top scientists and colleagues to optimize compounds in a new modality and this role will play an integral part in their structure-based drug design efforts on multiple programs.
The main function of this role is to leverage modern techniques for crystallization and structural determination of protein complexes and be the resident expert and driving thought leader in structural biology.
Responsibilities include but are not limited to;
• Solving novel X-ray crystal structures including crystallization robotics, data collection, and structure determination
• Detailed structural analyses and integration of structural observations with biochemical and biophysical data
• Managing external work done at contract research organizations
Formal descriptions can be supplied for interested candidates.
Qualified candidates will have a PhD in structural biology, biochemistry, analytical chemistry, or a relevant field and 8-10+ years of industry experience in a drug discovery setting. Must have in-depth experience in all aspects of protein crystallography and familiarity with in vitro biochemical methods, particularly ligand-binding assays (e.g. pulldowns, SPR/Biacore, FP, FRET, ITC, etc.). Experience with Art Robbins Gryphon, Scorpion, and CrysCam instrumentation, in silico modelling and experience with computational approaches to structure-based drug design is preferred.
Must be authorized to work in the US indefinitely to be considered and must be commutable to the Cambridge area or able to relocate with very limited assistance.
All resumes will be kept strictly confidential until you choose to pursue a specific opportunity with one of our clients.