Sr. Scientist, Translational Biomarkers

Sr. Scientist, Translational Biomarkers
Location: Cambridge, MA

 

HireMinds is partnered with an intimate team which is part of a global biopharma organization that is seeking your expertise in Translational Biomarker efforts.  In this translational biology role you’ll oversee collaborations with academic investigators or industry partners on in vivo pharmacology aspects of each program rare disease, neuromuscular, immune-metabolism and other disease areas to identify best animal models applicable to advance research studies. In this role you will report to the Senior Director of Translational Medicine and lead a team of associates in hands-on laboratory efforts of in-vitro/in-vivo/ex-vivo translational research.  You’ll guide development of pharmacodynamic markers of target engagement and predictive clinical efficacy and disease biology markers.  You’ll be adept with establishing and cultivate relationships with external partners, clinical and academic collaborators and CROs for basic and translational research programs as well. If this exciting career opportunity interests you reach out the HireMinds team today to learn more and apply. 

You’ll Be Responsible For: 

•    Maintaining an awareness of new/emerging techniques, tools and clinical findings relevant to the field of translational biology and cellular models to facilitate optimal biomarker and disease model efforts. 
•    Contribute relevant scientific expertise, strategy, and experimentally-derived insights as a member of multidisciplinary project teams working to drive the preclinical to clinical translation of pipeline assets. 
•    Plan and implement and manage lab associates in the execution of (in-vitro/in-vivo/ex-vivo) translational research. 
  Experience spanning pharmacodynamic (PD) markers of target engagement and markers for predictive or correlating with clinical efficacy and disease biology. 
•    Ability to establish and cultivate relationships with external partners, clinical and academic collaborators and CROs for basic and translational research
•    Analyze and interpret experimental data readouts and present results at internal meetings and scientific conferences or to key stake holders within the organization when called upon. 
•    Contribute to preparation of study reports, regulatory filings and project presentations or parts of IND filings. 
•    Provide high-level updates and advice to program leads and senior management, including evaluation of data and their potential impact on drug programs and clinical/regulatory strategy
•    Manage 1 or 2 junior level Associates or scientists in their daily activities and mentor them in their own career development. 

You’ll Bring With You: 

•    Ph.D. with 5+ years of laboratory experience in an academic or industry setting with exhibited clinical biomarker contributions. 
•    Demonstrated application of expertise to translational drug discovery in multiple therapeutic areas including: rare diseases, neuromuscular disorders, kidney, and immune-metabolism. 
•    Ability to manage and mentor lab staff and oversee daily lab activities. 
•    Knowledge of preclinical and clinical biomarker discovery and development in various disease models through IND stages preferred. 
•    Deep understanding of preclinical PK/PD/efficacy relationships and their translation to the clinic. 
•    Strong interpersonal and communication skills with an enthusiasm for participating in a fast-paced environment characterized by rigorous science and innovative thinking. 
•    Ability to contribute as a team player who communicates in an open, clear, complete, timely and consistent manner with peers, reports, and management.