Sr. Scientist, Translational Biomarkers
Location: Cambridge, MA
You’ll Be Responsible For:
• Maintaining an awareness of new/emerging techniques, tools and clinical findings relevant to the field of translational biology and cellular models to facilitate optimal biomarker and disease model efforts.
• Contribute relevant scientific expertise, strategy, and experimentally-derived insights as a member of multidisciplinary project teams working to drive the preclinical to clinical translation of pipeline assets.
• Plan and implement and manage lab associates in the execution of (in-vitro/in-vivo/ex-vivo) translational research.
Experience spanning pharmacodynamic (PD) markers of target engagement and markers for predictive or correlating with clinical efficacy and disease biology.
• Ability to establish and cultivate relationships with external partners, clinical and academic collaborators and CROs for basic and translational research
• Analyze and interpret experimental data readouts and present results at internal meetings and scientific conferences or to key stake holders within the organization when called upon.
• Contribute to preparation of study reports, regulatory filings and project presentations or parts of IND filings.
• Provide high-level updates and advice to program leads and senior management, including evaluation of data and their potential impact on drug programs and clinical/regulatory strategy
• Manage 1 or 2 junior level Associates or scientists in their daily activities and mentor them in their own career development.
You’ll Bring With You:
• Ph.D. with 5+ years of laboratory experience in an academic or industry setting with exhibited clinical biomarker contributions.
• Demonstrated application of expertise to translational drug discovery in multiple therapeutic areas including: rare diseases, neuromuscular disorders, kidney, and immune-metabolism.
• Ability to manage and mentor lab staff and oversee daily lab activities.
• Knowledge of preclinical and clinical biomarker discovery and development in various disease models through IND stages preferred.
• Deep understanding of preclinical PK/PD/efficacy relationships and their translation to the clinic.
• Strong interpersonal and communication skills with an enthusiasm for participating in a fast-paced environment characterized by rigorous science and innovative thinking.
• Ability to contribute as a team player who communicates in an open, clear, complete, timely and consistent manner with peers, reports, and management.