Our Cell Therapy client in Cambridge, MA is looking to add a Sr. Scientist to their In Vivo Pharmacology team! Role will serve as the lead in vivo scientist for discovery research programs from lead identification to clinical development. Will design and conduct in-vivo experiments to evaluate the activity and safety of T cell therapeutics in mouse models, provide scientific input and work collaboratively with departments across the organization. Practical knowledge of ex-vivo primary cell manipulations, tissue culture and immunoassays are highly desirable. The ideal candidate should have expertise in preclinical in vivo evaluation of T cell therapeutics in an industry setting.
- Assess the therapeutic potential of T cell therapeutic candidates using in vivo tumor models. Establish xenograft tumor models. Conceive, design, and execute efficacy, pharmacokinetic/pharmacodynamic (PK/PD), safety and mechanism of action (MOA) studies both in vivo and ex vivo. Perform necropsy, blood, and tissue collections.
- Initiate and manage in vivo safety and efficacy studies at various external CROs as needed.
- Perform tissue culture of established cell lines and primary human cells.
- Develop and perform cell-based functional assays and/or ex-vivo assays to evaluate anti-tumor activity and MOA of drug candidates.
- Collect and interpret data, prepare study reports, present results internally and at scientific conferences.
- Keep a study record by maintaining a detailed, accurate laboratory notebook.
- Supervise and mentor research associates/junior staff.
- Participate in the development of scientific manuscripts and abstracts, contribute to regulatory filings (IND, etc).
- Perform literature searches/reviews as necessary.
- A dynamic individual who likes to contribute as part of a passionate, growing team.
- B.S. in a life science (with 10+ years of experience), M.S. (with 6+ years of experience) or Ph.D. (with 3+ years of experience) in an industry setting. Experience with in vivo immuno-oncology drug development, particularly CAR-T, is highly desirable.
- Must be proficient in handling small laboratory animals, xenograft tumor model development and monitoring, compound administration (iv, ip, sc, po), common animal procedures, blood collection and necropsy/tissue harvest.
- Experience performing tissue culture of established cell lines is required, experience with primary human cell culture is preferred.
- Experience with cell-based assays of immune cell function including cytokine profiling, proliferation, multi-color flow cytometry, qPCR is preferred.
- Experience using in vivo data collection software, Microsoft Office, and GraphPad Prism.