Sr. Scientist, Cell Therapy

Our growing Cell Therapy Client here in Cambridge, MA is expanding and looking to add a hands-on Sr. Scientist to their team!  Their mission is to pioneer the development of controllable cell and gene therapies to deliver transformative outcomes for patients with intractable diseases.  This role will be a part of the Cell Therapy department and act as a key contributor to preclinical research supporting Cell Therapy program research and development.  Responsibilities include be not limited to: 

  • Lead pre-clinical proof of concept research activities toward the development of cell therapy products
  • Mentor and/or mentor a team of scientists/research associates in the design, execution and analysis of experiments that support programs
  • Design, develop and apply cell-based immune assays, including engineering of human T and NK cells
  • Make independent, intellectual, and technical contributions to projects, while working on a collaborative team
  • Isolate immune cells from human blood and tissue and conduct ex vivo engineering, differentiation, characterization, and/or in vivo adoptive cell transfer studies
  • Independently design experiments, meticulously execute bench work, troubleshoot assays, analyze data, and communicate findings
  • Present results at internal meetings

Requirements: 

  • PhD in Immunology or a related field with 3+ years of industry experience
  • Demonstrated expertise in ex vivo immunology methods including T and NK cell genetic engineering (gene transfer or gene editing), functional assay development using techniques such as multi-color flow cytometry, cytotoxicity assays, cytokine quantitation
  • Ability to quickly learn and adapt to fast paced, rapidly changing start-up environment
  • Scientific rigor in the design, execution, analysis, and troubleshooting of scientific experiments
  • Experience leading and driving research projects
  • Highly motivated team contributor, with ability to work independently and collaboratively

Preferred: 

  • Experience with tumor infiltrating lymphocytes (TIL)
  • Viral vector transduction of primary human immune cells
  • Cellular immunotherapy experience

*Must be authorized to work in the US for an indefinite amount of time.