Sr. Associate Scientist, T-Cell Biology

Our Cell Therapy client in Cambridge, MA is growing and looking to add a Sr. Associate Scientist to their T-Cell Biology team!  Our ideal candidate will have experience in T cell biology or immuno oncology to help build and advance their T cell therapy portfolio. Role will support the development of novel T cell products from discovery through pre-clinical development. Responsibilities include but not limited to:  

  • Generation and analysis of in vitro data to identify optimal binders and BOXR transgenes for lead selection of BOXR T cell candidates against various solid tumor indications.
  • Evaluate CAR and BOXR T cell function with in vitro cell-based assays including cytotoxicity, proliferation and transgene-specific functional assays to evaluate efficacy and mechanism of action in suppressive environments.
  • Collaborate with in vivo scientists to design studies evaluating the safety and efficacy of CAR and BOXR candidates.
  • Prepare study reports and present results internally at team meetings
  • Contribute to scientific manuscripts and abstracts, as well as slide & poster presentations for scientific conferences.
  • Keep a study record by maintaining a detailed, accurate laboratory notebook.

Requirements:  

  • BS with 4-8 years or MS with 1-4 years of industry experience.
  • Experience with engineered T cell therapeutics (CAR-T, TCR) preferred.
  • Proficiency in tissue culture of primary cells and cell lines, cell based in vitro functional assays including cytotoxicity, proliferation, cytokine production.  
  • Experience with multicolor flow cytometry required
  • Familiarity with lentiviral or retroviral production and transduction of mammalian cells preferred.
  • Experience with ELISA, MSD, westerns and cytotoxicity assays desired, experience with qPCR a plus.
  • Proficiency using programs such as Excel, GraphPad Prism, FlowJo, and PowerPoint for data entry, analysis, and presentations