Sr. Associate Scientist, Cell Therapy

Our growing Cell Therapy Client here in Cambridge, MA is expanding and looking to add a Sr. Associate Scientist to their team!  Their mission is to pioneer the development of controllable cell and gene therapies to deliver transformative outcomes for patients with intractable diseases.  This role will be a part of the Cell Therapy department and act as a key contributor to pre-clinical research supporting Cell Therapy program research and development.  Responsibilities include be not limited to: 

  • Make independent intellectual and technical contributions to projects, while working on a collaborative team
  • Design, develop and apply cell-based immune assays, including engineering of human T and NK cells
  • Isolate immune cells from human blood and tissue and conduct ex vivo engineering, differentiation, characterization, and/or in vivo adoptive cell transfer studies
  • Perform ex vivo analysis of samples from in vivo adoptive cell transfer studies, including immunophenotyping and serum analysis
  • Independently design experiments, meticulously execute bench work, troubleshoot assays, analyze data, and communicate findings
  • Present results at internal meetings

Requirements

  • BS/MS with 3+ yrs experience in an industry setting (job title will be DOE)
  • Demonstrated expertise in ex vivo immunology methods including T and NK cell genetic engineering (gene transfer or gene editing), functional assay development using techniques such as multi-color flow cytometry, cytotoxicity assays, and cytokine quantitation
  • Ability to quickly learn and adapt to fast paced, rapidly changing start-up environment
  • Scientific rigor in the design, execution, analysis, and troubleshooting of scientific experiments
  • High level of motivation and ability to work both independently and collaboratively

Preferred: 

  • Viral vector transduction of primary human immune cells
  • Cellular immunotherapy experience
  • Experience with tumor infiltrating lymphocytes (TILs)

*Must be authorized to work in the US for an indefinite amount of time.