Senior Scientist, iPSC Reprogramming

Scientist II/Sr. Scientist, iPSC Reprogramming
Waltham, MA

Our client is a cell and gene therapy technology company built to power the development of transformative cell and gene therapies today and for many decades to come. They are actively recruiting a Scientist II / Sr. Scientist, iPSC Reprogramming.  This individual will report to the Associate Director, Regenerative Medicine and will possess excellent scientific/technical skills. This person will be a part of the Research and Development team to establish novel reprogramming technologies and ultimately generate clinical grade induced pluripotent stem cell (iPSC) lines.  

Here’s What You’ll Do:

  • Plan, lead and execute activities supporting development of novel non-integrating reprogramming technologies and ultimate creation of clinical grade iPSC lines
  • Manage a team of scientists focused on iPSC reprogramming
  • Derive, culture, bank, and characterize iPSC lines
  • Develop and optimize analytical methods to assess reprogrammed iPSCs
  • Schedule and resource project team’s day-to-day work
  • Track and present on project progress both internally and in cross-functional forums
  • Take the lead on the project’s scientific strategy, identifying risks and mitigations as appropriate
  • Stay current on relevant science and present at scientific conferences


  • PhD with 5-8 years of relevant experience; or a MS with 8-10 years of industrial experience, or BS with 10+ years of industrial experience
  • Three or more years of industry experience strongly preferred
  • Experience managing small teams of scientists
  • Background in stem cell biology focused on iPSC reprogramming with relevant publications in peer-reviewed journals. Background knowledge in iPSC genetics and epigenetics is desired.
  • Demonstrated experience in evaluating pluripotent stem cell lines
  • Hands on knowledge of cutting-edge techniques in the field of reprogramming
  • Experience in molecular biology with an emphasis on mRNA synthesis, splicing, and delivery
  • Demonstrated experience in assays including PCR, immunostaining, flow cytometry, ELISA, genetic and epigenetic assessment
  • Gene editing experience (CRISPR/Cas9, TALEN, etc) is preferred
  • Detail-oriented, organized, critical-thinking and technically competent
  • Background knowledge on cell therapy process development and manufacturing is preferred
  • Highly adaptable and responsive, and committed to completing tasks in a timely fashion
  • Demonstrated ability to work in a dynamic environment as a team player with a strong work ethic
  • Excellent team player with good interpersonal and communication skills
  • Excellent oral and written communication skills, including supporting documentation in laboratory notebooks and study reports for regulatory filing activities