Senior Scientist, In Vivo Pharmacology

Senior Scientist, Pharmacology (CRISPR)
Location: Cambridge, MA

 

  HireMinds is partnered with a biotech founded by pioneers of CRISPR technologies who have conceived an RNA modulation platform focusing on diseases of high unmet need. Utilizing technology based on novel CRISPR-Cas systems this team  can precisely and efficiently engineer the transcriptome without permanent modification of the DNA genome.  They are seeking your expertise in pharmacology disease modeling to identify and develop in vivo disease models to evaluate the efficacy, pharmacodynamics (PD), safety, and mechanisms-of-action of drug candidates. You will collaborate with peers on Gene Regulation platform efforts and Delivery team on testing a variety of delivery modalities in advancing the company therapeutic delivery approach in a variety of therapeutic areas.  You will serve as a hands-on pharmacology expert on the team and work closely with colleagues and the scientific founders to drive forward the research and development strategy in this growing biotech environment. If you are ready for an exciting leadership role in epigenetic editing contact the HireMinds Biotech team today to learn more and apply.
 

In This Role You’ll Be Responsible For:

•    Identifying key experiments and development of in vivo disease models to facilitate testing experimental hypotheses on an RNA modifying CRISPR platform. 
•    Evaluations and decision making regarding efficacy, pharmacodynamics, safety, and mechanism-of-action of drug candidates. 
•    Independently execute in-house and external CRO studies, analyze data, share conclusions, and propose follow up experiments with team and management. 
•    Identify implementation risks inherent in the experimental approaches and propose alternative strategies.
•    Conceive and implement review Protocols and SOPs for pharmacology experiments. 
•    Maintain familiarity with relevant literature in the CRISPR gene editing, RNA, and gene regulation space. 
•    Test viral and/or non-viral delivery strategies in collaboration with delivery teammates. 
•    Examine data and prepare technical reports, summaries, and present at team meeting .

You’ll Bring With You: 

•    PhD in Pharmacology, Cell or Molecular Biology with 4+ years of industry experience in drug development setting with proven career accomplishments. 
•    Track record of Academic and Industry hands-on experimentation with in vivo disease models including administration of test compounds and collection of blood and tissue samples.
•    Hands-on expertise with a variety of molecular and cellular biology techniques including but not limited to nucleic acid isolation, RT-qPCR, ELISA, immunohistochemistry, and western blotting. 
•    Analytical problem solving abilities to approach novel scientific questions and ability to adapt to changing priorities and deadlines in an evolving biotech setting. 
•    Excellent planning, organization, and time management skills, including the ability to support and prioritize multiple projects and guide team activities to meet company goals
•    Desire to be part of a rapidly evolving organization which requires flexibility, and a willingness to take on novel discovery efforts through implementing new strategies and by applying cutting-edge technologies and methods