Senior Scientist, Hypoimmunogenic Stem Cell

Senior Scientist, Hypoimmunogenic Stem Cell

  HireMinds is helping our Biotech client grow their Universal Stem Cell team and needs your expertise in Hypoimmunogenic research. Our client is taking stem cell therapy to the next level with new iPSC therapies. To do this they will need your expertise in building hypoimmunogenic testing and iPSC cell lines for clinical use. You will work with research, manufacturing, and clinical stage projects in reporting and developing protocols in the creation of high-quality stem cells for regenerative medicine programs. You will also work with a collaborative team on internal and external partnered programs in finding successful therapies for patients in need. If you are open to this exciting laboratory role contact the HireMinds Lifesciences team today.

 

In This Role You Will:

  • Guide research on the generation and characterization of hypoimmunogenic iPSCs
  • Develop in vitro immunogenicity studies to characterize the interaction between immune system and iPSCs derivatives
  • Work Hand-on with in vitro immunology including: cytotoxicity assays, cytokine profiling, proliferation assays, flow cytometry, ELISA and ELISpot
  • Work on developing protocols and experiments on differentiation of iPSCs into desired cell types
  • Work with external CROs for outsourced in vivo research activities, including study design, monitoring, and data analysis
  • Lead assessment of in vivo immunogenicity studies with syngeneic and allogeneic host models
  • Contribute to cell banking strategy and execution with weekly scheduled tasks
  • Contribute to documentation and help devise protocols in preparation for iPSC manufacturing and immunogenicity studies with manufacturing teams
  • Contribute to scientific literature, publications, and scientific conferences of relevance in the field

You Will Be Required To Have:

  • Ph.D. 4+ or MS 8+ years of experience in industry biotech or pharmaceutical setting preferred with immunology and stem cell therapies preferred
  • 3+ years of industry biotech or pharmaceutical experience is preference, but client will consider strong Post-Doctoral candidates with relevant publication records in the field
  • Expertise in transplant immunology or immune-evasion strategies for universal cell therapies
  • A preference for exposure to gene editing and molecular technologies is preferred in: qPCR/ddPCR, CRISPR-Cas9, TALENs, and RNA-guided nuclease-based editing
  • Ability to execute on testing assays including: Immunostaining, flow cytometry, ELISpot, and ELISA
  • Adaptability and eagerness to troubleshoot or adjust to scientific changes as necessary
  • Ability to communicate effectively with cross-functional teams and contribute to written reports which will be included in regulatory or clinical filings