Senior Scientist, Genetic Engineering

Senior Scientist, Genetic Engineering
Boston, MA

Our client is a pre-clinical, VC-backed biotechnology company that is leveraging naturally-derived extracellular vesicles (EVs) to deliver gene therapies in vivo. They are operating on a hybrid-virtual model. Meetings are mostly virtual, but teams will meet in person to whiteboard strategy, visit partners to advance programs, and celebrate wins!

THE PERSON AND ROLE

The Senior Scientist position is full-time and will be100% in person, conducting benchwork. You will work directly with the Sr. Director of Research to manage your scientific programs while providing critical scientific leadership and genetic engineering guidance. You should be very comfortable both at the bench-designing, executing on and troubleshooting experiments and with managing a team of scientists.

KEY RESPONSIBILITIES

  • Support the Senior Director or Research, building and managing a team of junior scientists to drive project development, provide technical expertise for the design, implementation and troubleshooting of experiments, and ensure deliverables for both internal research projects and external scientific partnerships
  • Design and execute experimental plans to meet project milestones while maintaining the standards of scientific rigor and company culture and values
  • Coordinate and oversee the generation, collection, and sharing of experimental results and ensure that all protocols, reagents, data, and analyses are documented following data integrity principles and are made available in a timely manner
  • Attend and present at team meetings to share results, plan projects and experiments, and ensure that projects support team goals and company milestones 
  • Represent the company as a senior spokesperson at scientific, medical, regulatory, business and other professional meetings 
  • Contribute to and support expansion of the company’s intellectual property portfolio
  • Maintain comprehensive and up-to-date knowledge of extracellular vesicle biology, extracellular vesicles as therapeutics, and novel genetic engineering approaches

QUALIFICATIONS & EXPERIENCE

  • A genetic engineer with a PhD and 8+ years of postdoctoral experience in a relevant discipline
  • 3-5 years or relevant industry experience preferred
  • Experience in non-viral delivery/extracellular vesicles preferred 
  • Experience managing teams and/or collaborations, and ability to build strong, collaborative relationships and lead and motivate team members 
  • Hands-on experience in in vitro, ex vivo, and in vivo studies determining the efficacy of gene editing/gene therapy including quantification of editing efficiency/gene delivery, and effects on gene and protein expression in modified cells 
  • Experience in genetic, molecular, and cellular biology techniques, including plasmid construction, qPCR, RT-PCR, western blotting, microscopy, multiplexed flow cytometry, and techniques to assess gene editing efficiency and off-target effects (e.g. NGS) 
  • Expertise in genome editing technologies, including CRISPR-based methods, base-editing, prime editing, deletions and knock-ins and gene silencing 
  • Experience with mammalian cell culture and mouse models of human disease 
  • Ability to balance/prioritize research efforts across multiple programs, meet deadlines, and shift plans in service of a rapidly-changing startup environment 
  • Proficiency with FlowJo, Snapgene, Prism, R 
  • Exceptional communication, writing, organizational and time management skills 
  • Exemplary lab notebook practices, and attention to detail in recordkeeping; experience with electronic lab notebook (ELNs) preferred 

KEY POSITION DETAILS

  • Full-time Position 
  • Salary and benefits consistent with the competitive market of Boston/Cambridge and commensurate with experience 
  • In-person benchwork in Boston/Cambridge area and/or at partner headquarters location(s)
  • Current U.S. work authorization required