Senior Scientist, Gene Editing

Senior Scientist, Gene Editing

The Role:

We are looking for an experienced scientist with a strong background in mammalian genome editing to help expand our therapeutic capabilities and continue to improve our technology discovery platform. We are seeking curious, enthusiastic, competent, and self-motivated individuals to work in our company. A willingness to embrace our cultural values will be critical for success in this role. This is an exciting opportunity to help build a successful therapeutics company from an early stage.

Here’s What You’ll Do:

  • Design, implement, and troubleshoot experiments to develop and improve genome editing technologies in a variety of disease areas
  • Develop and optimize methods for introducing genome editing systems into human cells
  • Develop assays to tie genotypic changes to therapeutically relevant phenotypic changes
  • Provide scientific leadership
  • Analyze experimental data and present scientific results at team research meetings
  • Contribute to publications and patent applications
  • Follow advancements in the field of gene editing and gene therapy published in the literature and presented at conferences
  • Collaborate closely with the Computational Biology, Platform Development, and Pre-Clinical groups
  • Assist coordination of research associates and day-to-day laboratory operations


  • Ph.D. in biology, biochemistry, cell biology, or a related field with 5+ years of experience
  • Demonstrated experience leading scientific teams
  • Background in exploring therapies for metabolic diseases, inherited neurologic diseases, and/or other rare genetic disorders
  • Extensive expertise culturing, transfecting, and analyzing human cell lines and primary cells
  • Direct experience delivering genome editing systems to mammalian cells using multiple delivery methods including adeno-associated viruses (AAVs), Lipid Nanoparticles (LNPs), and nucleofection
  • Mastery of modern molecular biology techniques including DNA/RNA extraction, PCR, qPCR, and NGS
  • Experience developing, troubleshooting, and optimizing cell-based assays and translating insights from those experiments into therapeutically relevant endpoints
  • Outstanding communication skills (verbal and written)
  • Demonstrated ability to collaborate in a team-oriented environment
  • Industry experience strongly preferred
  • Participation in the preparation of INDs, NDAs or other regulatory submissions is an advantage