Senior Research Associate, Technology Development

Senior Research Associate I/II, Technology Development
South San Francisco

Our client is seeking a highly motivated biological scientist to expand efforts in the development of novel epigenome engineering tools for therapeutic and cell therapy applications.

The successful candidate will develop and execute high-throughput experiments in mammalian cell lines, and work collaboratively with colleagues to build discovery pipelines that enable potentially transformative technologies for a variety of current and future therapeutic indications. They will contribute broadly across multiple technical areas to accelerate the introduction of programmable epigenetic editing as an effective therapeutic modality.

This position requires ambition, adaptability, and a team-oriented mindset, but also a strong ability to organize parallel projects and work independently to establish pipelines in uncharted research territories.


  • Implement high-throughput screening platforms for gene & protein expression analysis
  • Develop DNA constructs, CRISPR libraries, and engineered cell lines
  • Coordinate tasks across multiple projects, demonstrating prioritization and planning
  • Effectively execute experiments in line with project timelines and strategic goals


  • BS/MS in molecular biology, biochemistry, bioengineering, or related fields, and 2+ years of relevant research experience in industry or academia
  • 1+ year experience in molecular cloning and mammalian cell culture


Proficient working knowledge and experience in any of the following:

  • High-throughput pooled and/or arrayed CRISPR/(d)Cas screening
  • Flow cytometry, FACS, ELISA, RT-qPCR, and related gene/protein expression analysis methods
  • Maintenance of, and nucleic acid delivery to, primary and/or iPS/ES cell types
  • High-throughput laboratory automation (e.g. liquid handling)
  • Lentiviral vector design, packaging, transduction, and cell line creation
  • Data manipulation/analysis in R, Python, JMP, Prism, or similar
  • Plasmid design with SnapGene, Benchling, or similar
  • NGS assay design and illumina library preparation

The salary range for this position is $90,000 USD to $110,000 USD annually. This salary range is an estimate, and the actual salary may vary based on various factors, including, without limitation, individual education, experience, tenure, skills, and abilities, as well as internal equity and alignment with market data, including potential adjustments for geographic location.