Our Cell Therapy client in Cambridge, MA is growing and looking to add a Scientist, Molecular Biology to their Discovery Research team! In this highly impactful role, Scientist will be responsible for molecular biology efforts as they apply to T cell engineering, platform technology development, and screening efforts to advance drug discovery programs.
- Play an active role in drug discovery programs from target hypothesis through IND-enabling studies by applying expertise in molecular immunobiology and cancer biology
- Demonstrate theoretical knowledge of immune oncology related genes and pathways and motivation to learn new approaches to keep up with latest developments in the field
- Independently conceptualize and perform cell-based functional assays (cell lines and primary human cells) to support target validation, screening and mechanism of action studies
- Design and perform experiments for expression of proteins and nucleic acids in mammalian cells and for in vitro modification of primary cells using a variety of expression modalities, including but not limited to transient and stable DNA and mRNA transfection, and viral transduction etc.
- Analyze, critically interpret data and share results with a broad internal audience as required
- Propose novel projects based on internal results, external partners, and published reports.
- Keep meticulous experimental records and maintain ELN entries; Contribute to report writing and other publications as needed.
- Work collaboratively with others in the team and cross-functionally with other groups to support preclinical and translational drug development.
- PhD with 0-2 years post graduate experience in immunology, cancer biology, cell biology, molecular biology, genetics, bioengineering, or a related discipline. T cell molecular biology experience is a plus.
- Experience and in-depth knowledge of signaling and transcriptional pathways involved in T cell and cancer biology
- Expertise and hands-on experience culturing primary human cells and cell lines. T cell experience is a plus.
- Knowledge of gene editing techniques including CRISPR-Cas9 is highly desirable
- Excellent oral and written communication skills, and ability to simplify complex biological concepts to peers.