Our Cell Therapy client located in Cambridge, MA is growing and looking to add a Scientist I/II, In Vivo Pharmacology to their team! Role will serve as a lead in vivo scientist for discovery research programs from lead identification to clinical development. Will design and conduct in-vivo experiments to evaluate the activity and safety of T cell therapeutics in mouse models, provide scientific input and work collaboratively with departments across the organization. The ideal candidate would have industry experience in in vivo immuno-oncology drug development, particularly CAR-T.
- Assess the therapeutic potential of T cell therapeutic candidates using in vivo tumor models.
- Establish xenograft tumor models.
- Conceive, design, and execute efficacy, pharmacokinetic/pharmacodynamic (PK/PD), safety and mechanism of action (MOA) studies both in vivo and ex vivo.
- Perform necropsy, blood, and tissue collections.
- Initiate and manage in vivo safety and efficacy studies at various external CROs as needed.
- Perform tissue culture of established cell lines for xenograft model development.
- Perform ex-vivo assays to evaluate anti-tumor activity and MOA of drug candidates.
- Collect and interpret data, prepare study reports, present results internally and at scientific conferences.
- Keep a study record by maintaining a detailed, accurate laboratory notebook.
- Participate in the development of scientific manuscripts and abstracts, contribute to regulatory filings (IND, etc.).
- Perform literature searches/reviews as necessary.
- A dynamic individual who likes to contribute as part of a passionate, growing team.
- B.S. in a life science (with 10 years of experience), M.S. (with 8 years of experience) or Ph.D. (with 1 year of experience) in an industry setting. Experience with preclinical oncology drug development is required, immuno-oncology drug development is preferred.
- Must be proficient in handling small laboratory animals, xenograft tumor model development and monitoring, compound administration (iv, ip, sc, po), common animal procedures, blood collection and necropsy/tissue harvest.
- Experience performing tissue culture of established cell lines is required
- Experience using in vivo data collection software, Microsoft Office, and GraphPad Prism is required.
- Experience with ex vivo cell-based assays of immune cell function including cytokine profiling, proliferation, multi-color flow cytometry, qPCR is preferred.
- The is a lab-based position, including prolonged periods of standing, sitting and working at a desk/computer.
- Occasional weekend work is required.
- Occasional lifting of heavy objects (<50 lbs).