Scientist, Gene Therapy (RNA)

Scientist, Gene Therapy (RNA)
Location: Philadelphia, PA

  HireMinds is representing a stealth-mode Philadelphia, PA base biotechs team’s buildout in taking on novel next-generation gene therapy approaches to AAV. As part of this new team you will work in the lab and with colleague in developing novel CNS therapies using a state-of-the-art new approach to NHP studies of engineered capsids. If you are a talented RNA/Molecular biologist take note.  In this role you’ll be responsible for advancing capsid discovery to identify and characterize novel engineered AAV capsids with a novel platform. In addition you should be a builder type that can help a team in a variety of ways as this is a true start-up environment you’ll contribute to. If this sounds exciting for your career contact Tricia Hanley on the HireMinds team today to learn more and apply. 

You’ll Be Responsible For: 

•    Providing RNA biology expertise in the laboratory as well as cloning in order to help prioritize top candidates for further validation. 
•    Expertise with RNA extraction techniques and preparation of libraries for RNA sequencing from primate tissue. 
•    Oversight of all aspects of library production with meticulous detail from viral vector design, cloning, and library design. 
•    Preparation of samples for next generation sequencing libraries.
•    A passion for keeping up-to-date with relevant scientific literature and advancements in RNA biology and  library production to troubleshoot and improve methodologies for the team. 
•    Identify implementation risks inherent in the experimental approaches and propose alternative strategies.
•    Independently execute studies, analyze data,  and share gained understanding of outcomes in internal forums and with external collaborators. 
•    Examine data and prepare technical reports, summaries, and present at team meetings and to management. 

You’ll Bring With You: 

•    PhD in Molecular Biology or Biochemistry and 2+ years of Postdoctoral training with a track record of high-impact scientific publications in peer-reviewed journals. 
•    Preferred background of study in neuroscience and/or have experience with analyzing RNA sequencing datasets.
•    Expertise in the preparation of RNA-sequencing libraries is required. 
•    Prior experience in the analysis of next-generation-sequencing datasets through past work is desired. 
•    Extensive hands-on experience in molecular, cellular and biochemical approaches and viral vector design (AAV, lentivirus or adenovirus), with an emphasis on DNA and RNA-based techniques: trizol extraction, cloning, in situ hybridization, RNAscope etc. 
•    Familiarity with cell culture, qPCR platforms, and viral delivery protocols is preferred.
•    Willingness to implement new strategies, cutting-edge technologies and methods. Ability to master new concepts and technologies quickly and run experiments independently.
•    Analytical thinker with excellent problem-solving skills and the ability to adapt to changing priorities and deadlines.
•    Scientifically rigorous, highly organized, with excellent time management skills in keeping industry timelines in focus. 
•    Ability to work in an evolving environment, collaborating with various colleagues across multiple departments.
•    Will consider Scientist or Sr. Scientist titles pending candidate experience level.