Research Associate, In Vivo Pharmacology

Our Cell Therapy client in Cambridge, MA is looking to add a Research Associate to join our their In Vivo Pharmacology team! Role will conduct in-vivo experiments to evaluate the anti-tumor activity and safety of T cell therapeutics in mouse tumor models. The ideal candidate would have expertise in preclinical in vivo oncology drug development, preferably T cell therapeutics, in an industry setting. 

Responsibilities include:  

  • Work as a key member of the In Vivo Team to assess the therapeutic potential and safety of T cell therapeutic candidates using xenograft tumor models in immunodeficient mice.
  • Plan and execute in vivo studies (under the guidance of Senior scientific staff) including:
    • Establish xenograft tumor models, conduct anti-tumor efficacy, pharmacokinetic/pharmacodynamic (PK/PD), and tolerability/toxicology studies
    • Perform dosing (IV, SC, IP, PO) of test articles, necropsy, blood, and tissue collections.
    • Perform daily health monitoring observations.
  • Perform tissue culture of established cell lines
  • Collect and interpret data, prepare study reports, present results at team meetings and internal presentations as needed. 
  • Contribute to scientific manuscripts and abstracts, as well as slide & poster presentations.
  • Perform literature searches/reviews as necessary.
  • Keep a study record by maintaining a detailed, accurate laboratory notebook.
Requirements:  
  • B.S. in a life science with 1+ years of in vivo experience in an industry setting, with oncology in vivo experience preferred.
  • Must be proficient in handling small laboratory animals (mice), compound administration (IV, SC, IP, PO), blood collection and necropsy/tissue harvest.
  • Experience with xenograft tumor models is preferred.
  • Must have tissue culture experience.
  • Experience using in vivo data collection software, Microsoft Office, and GraphPad Prism is preferred.
  • Strong time management skills and ability to multi-task effectively is essential.
Physical Requirements:  
  • The is a lab-based position, including prolonged periods of standing, sitting and working at a desk/computer.
  • Occasional weekend work is required.
  • Occasional lifting of heavy objects (<50 lbs).