Head of Pharmacology

Our pharmaceutical client is looking to add a new Head of Pharmacology to their team here in Watertown, MA!  This role will be responsible for ensuring pharmacology support and analysis across programs in both oncology and inflammation and provide expertise in efficiently driving to high-quality development candidates for lead programs.  In addition, the Head of Pharmacology will be responsible for building and maintaining in-house vivarium facilities and infrastructure.   Other responsibilities include but not limited to: 


  • Manage and mentor a team of pharmacology scientists, ensuring adequate support for in vivo efficacy, safety and PK/PD studies across the portfolio
  • Be the in vivo expert and contribute scientifically and technically to the strategy and tactics of multiple projects in the pipeline
  • Hands on participant in the design, direction, execution, and analysis of in vivo studies to profile compound for proof of mechanism and proof of concept.
  • Choose the right mechanistic or disease models appropriate for the target and the biology
  • Integrate data and information from those studies to provide a detailed understanding of the pharmacology of the compounds and to be enable understanding of in vitro-in vivo correlations
  • Perform PK-PD modeling to help inform on human dosing
  • Identify, initiate, and manage productive collaborations with CROs and academic labs as appropriate to driving projects forward
  • Lead the build out and establish new vivarium space at the new facilities. This will include supporting the appropriate strategy to enable both infrastructure and personnel to ensure this facility is functional in CY 2020
  • Proactively recognize and solve technical and scientific issues to assure high quality data from external resources
  • Work effectively with other disciplines, including cell biology, DMPK, and safety/tox to collectively build the preclinical data package for clinical candidate nomination
  • Lead a project from early discovery to development candidate.
  • Participate in evaluation of targets and projects to continually refresh the drug discovery pipeline and progress the platform
  • Contribute to building a positive, team-oriented biotech culture





  • PhD in pharmacology or biology, with 10+ years’ direct pharmaceutical experience beyond postdoctoral work
  • Ability and willingness to lead from the bench
  • Direct experience working in smaller companies is highly preferred
  • A track record in using their pharmacology experience to drive projects to development candidate stage
  • Direct experience in supporting IND strategy and documentation, including writing relevant pharmacology sections of INDs
  • Demonstrated ability to lead teams to drive go/no go decisions
  • Proficiency and hands-on experience with acute and chronic in vivo models of oncology, immuno-oncology, or autoimmunity
  • Ability to model PK-PD using programs such as WinNonLin is a plus
  • Excellent project management skills and the ability to effectively manage CROs and to facilitate interactions with academic labs and companies to ensure project progression
  • Experience in managing vivarium space, including personnel and infrastructure