Director of Medicinal Chemistry

Director of Medicinal Chemistry

Hybrid / Full-time

Must be located in NYC Metro Area or MA

Our client, a NYC & Boston-based pre-clinical stage biotech pioneering small molecule medicines for targeted protein stabilization, is seeking a Director of Chemistry to join their expanding high-profile team. The ideal candidate has a working knowledge of early stage hit-to-lead optimization, structure-based drug design and the ability to be dynamic working across multiple projects in the platform. You must have people and project management expertise to be successful in this position.

Interested? If you meet the requirements below, please email me!

You will:

  • Define medicinal chemistry strategy aligned with project goals and lead external chemistry teams to efficiently execute medicinal chemistry plans
  • Lead team/people and project management
  • Rapidly progress leads towards clinical candidates
  • Influence scientific and business decision-making (project selection and resource
  • allocation)
  • Communicate strategy, objectives, progress & challenges to key stakeholders


  • Ph.D. in Synthetic Chemistry, Organic Chemistry, Medicinal Chemistry or similar
  • Experience in drug discovery/development in a biotech/pharmaceutical setting
  • Experience managing external CRO chemistry teams
  • Experience being the chemistry lead on multidisciplinary project teams, driving compound progression through screening runs towards key milestones
  • Experience in targeted protein degradation, heterobifunctional chemistry and/or deubiquitinase ligand discovery-based projects is desired
  • Experience with HTS triage and validation desirable
  • Understanding of both classic and contemporary synthetic chemistry methodologies
  • Strong medicinal chemistry understanding with a good knowledge of basic biology, pharmacology and ADME/PK principles that relate to drug discovery projects
  • Knowledge of several related disciplines, such as DMPK, pharmacology, toxicology, regulatory, clinical development, CMC
  • Strong publication record with proven track record of driving scientific projects of high quality