Associate Director, In Vivo Pharmacology (Oncology)

Associate Director, In Vivo Pharmacology (Oncology)
Location: Lexington, MA

 

HireMinds is seeking your expertise to guide in vivo pharmacology for a growing biotech organization in growth mode. In this role you’ll be relied upon to guide in vivo strategy and execution of in-house and external CRO in vivo modeling in oncology focused studies. You will be an integral part of in vivo strategy and guide efficacy and PK/PD key decision points in assessing small molecule programs. You will have an intimate team to build and work with as well as the majority of large studies will be conducted with CROs, but in-house processing and accessioning will be necessary to assess samples. If this role sounds like a great next step for your career advancement reach out to Chris Clancy and the HireMinds team today to apply and learn more. 

You’ll Be Responsible For: 

•    Oversight of strategy and execution of all in vivo pharmacology studies in the oncology focus: including tumor model selection, study design, and data and tissue collection. 
•    Establishment and fostering of productive relationships with external CROs to deliver high quality in vivo pharmacology data packages in collaboration with the R&D team. 
•    Work collaboratively with the Discovery Biology and Translational teams to explore mechanism of action of lead compounds, analyze and interpret PK/PD relationships, and test biomarker hypotheses with appropriate models.
•    Serve on cross-functional project teams as the in vivo subject matter expert and provide insight to key discussions on project strategy and go/no-go decision making. 
•    Author and gain approval for animal protocols with various IACUC bodies with in-house and external efforts. 
•    Review and ensure the quality of scientific data to meet regulatory expectations and author technical and regulatory documents/sections to support advancement of therapeutic IND filings to eventually advance into clinical programs. 

You’ll Bring With You: 
•    Ph.D. ~8 years industry experience with hands-on in vivo experience in biotech and/or pharma industry roles. 
•    Broad experience with in vivo tumor models, xenograft and syngeneic models
•    Hands-on expertise in techniques including tumor implantation and measurement, administration of therapeutics IV/IP (intraperitoneal, intravenous), bleeding, euthanasia, tumor dissection, processing and preservation
•    Ability to write detailed in vivo SOPS/protocols and direct the work of in vivo scientists/technicians in the lab setting. 
•    Demonstrated ability to effectively train, manage, and mentor associates on proper in vivo protocols and lab standards and procedures. 
•    A track record of contacts with external CRO partners in the oncology pharmacology function. 
•    Ability to adapt to a variety of program demands at early to clinical stage decision points and help make the best pharmacology decisions for each project as called upon.