Associate Director/Director, Discovery Biology and Pharmacology

Associate Director/Director, Discovery Biology & Pharmacology

Cambridge, Massachusetts

Full-time – On-site 60%, Remote 40%

Our client, a Cambridge based startup, is revolutionizing RNA delivery by leveraging new biology along the RNA-Glycobiology axis. Founded by world-experts in glycobiology and glyco-chemistry, they recently launched to harness the potential biology of glycoRNAs for delivery and immune modulation. Reporting to the Co-Founder, you will be directing the discovery biology team. You will be responsible for synthesizing data across disparate assays to form a hypothesis for a lead compound and target in vivo, and then design future in vitro and in vivo experiments to define a disease context in which this molecule is efficacious. This role requires knowledge of IND enabling experience and these assays will comprise the discovery pharmacology sections of future INDs.

Interested? If you meet the requirements below, please email me!

You will:

  • Manage a team of 3+ scientists internally and external CRO FTE’s in design and execution of translational studies
  • Provide expertise in hit-to-lead, SAR, and in vivo modeling assays and studies to team and oversee studies
  • Manage and oversee assay activities performed at CROs/CDMOs associated with data generation and analysis
  • Contribute to written pharmacology section of INDs
  • Design in vivo dosing experiments and oversee execution of modeling done with external CRO partners
  • Present research on a weekly basis to company leadership, and quarterly to investors and BOD
  • Maintain excellent written documentation of completed experiments (e.g. electronic lab notebook and study reports)


  • PhD molecular biology, biochemistry, immunology, biotechnology, or related field and 5+ years of industry experience
  • Experience in mentoring and managing lab teams with proven management experience
  • Previous experience with Hit-to-lead, SAR, and Validation stage compound decision making
  • Previous experience with contributions IND enabling studies
  • Ability to design and oversee in vivo modeling studies with CRO parnterships
  • Excellent writing and communication skills

All resumes will be kept strictly confidential until you choose to pursue a specific opportunity with one of our clients.