Discovery / Research

Scientist I/II, Bioanalytical Development Direct Hire MA

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Job ID: 15996 Direct Hire MA

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Our client is a public, mid-sized therapeutics company based in Cambridge with approved products already on market and a strong pipeline.  They are seeking an experienced Bioanalytical Scientist to join their Drug Discovery team to support non-clinical and discovery stage programs.      

The main function of this role is to develop and validate bioanalytical/analytical methods in support of the company's pipeline covering both preclinical and clinical studies. You will have the opportunity to work with the nonclinical team and manage CRO partnerships to ensure assays are well qualified/validated. 

Responsibilities include but are not limited to;
•  Development and validation of bioanalytical LC/MS methods for discovery non-GLP pharmacokinetic/pharmacodynamic studies, GLP toxicology studies and clinical studies.
•  Effectively collaborate with bioanalytical/analytical CROs to support GLP toxicology and clinical phase studies.
•  Review and finalization of method validation and bioanalytical reports.

Formal descriptions can be supplied for interested candidates. 

Qualified candidates will have a PhD in a Biology, Chemistry, or a related Life Sciences and 2-5+ years of experience (or a MS and 10+ years) in method development and validation of LC/MS-based assays.  Experience monitoring and managing external work at CROs is required.

Must be authorized to work in the US indefinitely to be considered and must be commutable to the Cambridge area or able to relocate with limited assistance.  

All resumes will be kept strictly confidential until you choose to pursue a specific opportunity with one of our clients.

Principal Computational Scientist Direct Hire MA

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Job ID: 15995 Direct Hire MA

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Our Global Biologics client is looking to add a Principal Computational Scientist to their team to support their Immuno-Oncology programs here in Cambridge, MA!  It is an exciting time to be a part of the Discovery teams!  This role will help with designing experiments, manage data, and use advanced statistical, machine learning, as well as computational techniques to discover new targets either to stop the growth of cancer or re-awaken the immune system to eradicate the cancer. Furthermore, the Data Scientist will collaborate with Early Development teams to guide the development of molecules against those targets with data-driven biomarker plans.  Other responsibilities include but not limited to:

  • Work with project teams to define scientific questions that can be addressed with an appropriately powered experimental designs
  • Supply any computational, statistical, machine learning, or modeling capability needed to synthesize from this design actionable recommendations relative to the team’s question
  • In collaboration with project teams, propose analysis strategies for target discovery, using methods based for instance on differential expression, co-regulation, correlated amplification, recurrent alterations, etc.; in so doing, also help devise statistical metrics for deciding significance, and ranking schemes for integrating data from many sources
  • Identify targets and biological contexts (e.g., T or B-cell repertoire, immune phenotypes, copy number, mutational, or expression signatures) in which therapies are likely to be beneficial by mining immune, genetic, genomic or screening data
  • Identify from patient and model system databases the epidemiology of these biological contexts and targets
  • Develop biomarker plans (e.g., selection, PD, efficacy) in collaboration with project teams
  • Manage and develop group of one or more associates and/ or contractors

Requirements:

  • Ph.D. in a computational, statistical, biophysics, or bioinformatics related fields.
  • A minimum of 8+ years project-based work in computational application to biology related fields, preferably Immuno-Oncology
  • Statistical programming skills like SAS/S-plus, R/Bioconductor and pipeline pilot or equivalents
  • Excellent understanding of immunology and hands-on research experience investigating complex lymphoid and/or myeloid cell subsets
  • First-hand multi-parametric data mining experience for target identification and biomarker discovery. For example, multivariate analysis; dimensionality reduction methods; parametric and non-parametric statistical methods; Bayesian statistics; pattern recognition or classification methods.
  • First-hand experience at integrating publicly or commercially available genetic, genomic, and immune datasets with novel experimental data to identify testable hypotheses
  • Developed communication and presentation skills and a successful track record of collaborating with cross-functional project teams
  • Demonstrated ability to lead projects of moderate scope, mapping-out critical path, milestones and timelines, as well as manage customer expectations with minimal supervision

Sr. Research Associate, Immunology Direct Hire MA

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Job ID: 15989 Direct Hire MA

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Our growing Cambridge, MA client is looking to add Scientist /Sr. Scientist, Protein Design to their team to help discover new antibody discovery platforms within the cancer immunotherapy space! Their mission is to develop best-in-class multi-specific and multi-functional immunotherapies, to enable patients to harness their own body to fight cancer. Responsibilities include but not limited to:

  • Develop and perform in vitro translational assays using human and murine immune cells with a higher degree of complexity and minimum supervision
  • Document all data and maintains high quality lab notebooks. Able to contribute to technical reports and patent/regulatory filings
  • May mentor peers and fill in for supervisor on lab related decisions

Requirements:

  • B.S. or M.S., with 3 or more years of industry working experience in the field of immunology
  • Demonstrated ability to independently conceive, execute, and interpret a complete range of experiments, as well as work effectively as a team member, contributing to discussions around own expertise while showing an understanding of the role of the other members
  • Experience in FACS analyses (multi-parameter, intracellular cytokine staining), familiarity with Flowjo program, cytokine analysis by ELISA, and multiplex assays (MDS or Luminex)
  • Experience in immune cell isolation of human and rodent original (e.g. density centrifugation, magnetic bead separation)

Senior Scientist, Immunology Direct Hire MA

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Job ID: 15988 Direct Hire MA

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Our growing Cambridge, MA client is looking to add Scientist /Sr. Scientist, Protein Design to their team to help discover new antibody discovery platforms within the cancer immunotherapy space! Their mission is to develop best-in-class multi-specific and multi-functional immunotherapies, to enable patients to harness their own body to fight cancer.  Responsibilities include but not limited to:

  • Independent and capable of establishing and executing on relevant biochemical and cellular assays to determine or validate cell surface expression and density of tumor-associated targets
  • Develop SOPs for key in vitro and ex vivo assays
  • Contribute or lead preparation of complex technical reports/patents
  • Prepare and lead presentations to a broad audience
  • Collaborate with In Vivo Pharmacology group to identify and develop PK and PD assays, including receptor occupancy to support non-clinical evaluation of NBEs
  • May contribute to scientific literature and represent Elstar at scientific conferences
  • May supervise junior scientists in the formulation and execution of experiments

Requirements:

  • Ph.D. in immunology, with at least 2 years of relevant, immunology, industry experience
  • Possess a broad-based knowledge in immunology drug discovery with relevant publications in peer-reviewed journals and good understanding of the company’s drug discovery process
  • Demonstrated experience in evaluating in vitro mechanisms of action, establishing biomarker correlations for biological therapeutics and/or working with murine tumor models
  • Experience in biologics or large molecule drug discovery in immuno-oncology
  • Strong communication and problem-solving skills and ability to thrive in a fast-paced and matrix environment

Research Associate/ Sr RA, Protein Analytics Direct Hire MA

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Job ID: 15971 Direct Hire MA

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Our growing Cambridge, MA client is looking to add a RA / Sr. Research Associate, Protein Analytics to their team to help discover new antibody discovery platforms within the cancer immunotherapy space!  This new growth hire will be a part of the Protein Engineering team and play a critical part in the newly forming Protein Analytics group.  Research Associate will support Company’s antibody discovery platform by assisting with the designing and development of analytical methods for the biophysical screening of hits and potential lead molecules.  Will perform techniques including peptide mapping by LC-MS/MS, intact mass analysis, MS/MS for protein and carbohydrate structural elucidation/quantification, disulfide mapping, SPR, BLI, epitope binning and mapping, and the binding kinetics of an antibody-antigen interaction

Requirements:

  • BS/MS in biochemistry, chemistry, biological sciences or related scientific discipline with at least 2+ years industry, hands on experience with biological mass spectrometry. 
  • Experience with qualification and validation of biochemical protein characterization methods is preferred. 
  • Understanding of biologics development is preferred as well as experience working with monoclonal antibodies. 

Research Associate / Sr. RA, Protein Engineering Direct Hire MA

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Job ID: 15964 Direct Hire MA

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Our growing Cambridge, MA client is looking to add a Research Associate I/II/Sr., Protein Expression to their team to help discover new antibody discovery platforms within the cancer immunotherapy space!  This new growth hire will be a part of the Protein Engineering team and play a critical part in the newly forming Protein Analytics group.  RA will assist with supporting the new antibody discovery platform by performing and executing the expression, production, purification, conjugation, and analysis of antibody in vivo surrogate and development candidates.  Other responsibilities include independent planning, execution of scientific experiments, interpretation and presentation of scientific data.

Requirements:

  • BS/MS in Life Sciences with emphasis on Biochemistry, and with 2+ years of industry experience in Molecular cloning, mammalian cell expression, and protein purification is required. 
  • Experience in designing expression constructs for mammalian or bacteria expression systems and protein analytical methods such as ELISA, HPLC, SDS-PAGE and Western blot analysis techniques are a plus.

Scientist / Sr. Scientist, Protein Engineering Direct Hire MA

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Job ID: 15963 Direct Hire MA

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Our growing Cambridge, MA client is looking to add Scientist /Sr. Scientist, Protein Design to their team to help discover new antibody discovery platforms within the cancer immunotherapy space!  This new growth hire will be a part of the Protein Engineering team and play a critical part in the newly forming Protein Analytics group.  Scientist will support the new antibody discovery platform by designing, performing and executing the expression, production, purification, conjugation, and analysis of antibody in vivo surrogate and development candidates.  Other responsibilities include independent planning, designing and execution of scientific experiments, interpretation and presentation of scientific data, and supervision of a research associate.

Required Experience

  • Ph.D. in Life Sciences with emphasis on Biochemistry, and with 2+ years of industry experience, or MS with 5+ years of experience, or a BS with 8+ years of experience. 
  • Experience in Molecular cloning, mammalian cell expression, and protein purification is required. 
  • Experience in designing expression constructs for mammalian or bacteria expression systems and protein analytical methods such as ELISA, HPLC, and Western blot analysis techniques are a plus.

Scientist /Sr. Scientist, Protein Analytics Direct Hire MA

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Job ID: 15962 Direct Hire MA

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Our growing Cambridge, MA client is looking to add Scientist /Sr. Scientist, Protein Analytics to their team to help discover new antibody discovery platforms within the cancer immunotherapy space!  This new growth hire will be a part of the Protein Engineering team and play a critical part in the newly forming Protein Analytics group.  Scientist will support the new antibody discovery platform by designing, developing, and implementing analytical methods for the biophysical screening of hits and potential lead molecules.   In addition, Scientist will determine binding affinity/kinetics measurement of pre-clinical antibody-like molecules, and design and execute epitope binning experiments in support of early stage discovery both using SPR/Biacore technologies. 

Requirements: 

  • Ph.D. in Life Sciences with emphasis on Biochemistry, and with 2+ years of industry experience, or MS with 5+ years of experience, or a BS with 8+ years of experience. 
  • Experience working on therapeutic antibody discovery programs and epitope binning a plus. 
  • Ability to manage multiple projects simultaneously with excellent written and verbal communication skills and the ability to work in cross-functional team environments.

Head of Vector Engineering Direct Hire MA

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Job ID: 15810 Direct Hire MA

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Growing Gene Therapy company at clinical stage is looking to add a Head of Vector Engineering to their Cambridge, MA team!  This role will lead the VE team to implement cutting-edge vector technologies and provide strategic vision! Will oversee the design, conduct and interpretation of vector studies to enable the company’s research and development goals and present finding to internal and external stakeholders.  In addition to technical responsibilities, this role will manage the team to ensure scientific rigor, and team continuity and excellence through hiring, training and performance management.  Will establish and manage scientific collaborations with external academic groups and CROs to advance program pipeline.  In addition, will work closely within cross-functional teams including cell line isolation, process development and analytical development teams to implement improved rAAV vector design to enable increased yield and quality metrics for discovery and on-going programs

Requirements:

  • PhD in Virology, Cell Biology, Molecular Biology, Biochemistry, Chemical Engineering or a related discipline
  • 7 or more years of industry experience preferred
  • Direct management and leadership experience
  • Experience in mammalian cell culture, molecular biology, protein biochemistry, immunoassays, flow cytometry, and quantitative PCR methods
  • Experience in the development of complex biological assays
  • Experience with statistical analysis software (SoftMax, JMP, SAS) preferred
  • Experience working with external contract labs (CMOs, CROs) is a plus

Sr. Toxicologist for clinical-stage biotech Direct Hire Massachusetts

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Job ID: 15758 Direct Hire Massachusetts

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Our well-funded Cambridge start-up client is seeking an experienced Toxicologist to lead pipeline projects by directing GLP & non-GLP studies with CROs and participating in Regulatory filings.  You will work closely with program leaders, clinical and regulatory teams to develop an overall toxicology development plan including lead optimization, candidate selection, IND-enabling studies, etc.

Responsibilities include but are not limited to;
•  Interact with CROs for quotes, cost estimates, and monitor study activities including protocol development and report generation.  
•  Provide strategic advice to senior leadership and relevant project teams regarding potential impact of study results on program and clinical/regulatory strategy.
•  Communicating with regulatory bodies in support of global regulatory submissions.

Formal descriptions can be supplied for interested candidates. 

Qualified candidates will have a Ph.D. in Toxicology or relevant field with a minimum of 3 - 5+ years of experience in nonclinical development and conducting regulatory toxicology studies.  More experienced candidates can also be considered.  Candidates who have DABT certification are welcome but it is not required to be considered.  Candidates must have experience in various aspects of toxicology study conduct including developmental and reproductive toxicology, carcinogenicity, toxicokinetics, and safety pharmacology as well as experience in designing, conducting, monitoring, and interpreting discovery and exploratory toxicology studies to assist lead optimization and candidate selection efforts.  Must also have experience in management of external CROs and representing Toxicology function to global regulatory agencies in support of submissions.  

All resumes will be kept strictly confidential until you choose to pursue a specific opportunity with one of our clients.

Associate Scientist, CAR-T Direct Hire MA

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Job ID: 15365 Direct Hire MA

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Our client is a highly-regarded cell/gene therapy company in the greater Boston area and they are seeking an experienced, highly-motivated Immuno-Oncology Associate Scientist to join their research and discovery team to work on next-generation CAR-T therapies in oncology! You will collaborate with and help other teammates troubleshoot assays, as well as identify and develop new targets and chimeric antigen receptors (CARs). The main function of this role is to support cell-based assays for T cell characterization, proliferation, and function, and to coordinate new research projects to overcome various obstacles within the tumor microenvironment.

Responsibilities:
•  Support diverse immunological assays to evaluate T-cell biology, including cell sorting (fluorescent and/or magnetic), multi-color flow cytometry, Luminex, cytokine profiling, etc.
•  Analyze experimental and flow cytometry data to identify promising new CAR candidates for subsequent development.
•  Work collaboratively/cross-functionally and use viral vectors to genetically modify T lymphocytes.?

Requirements:

•  BS/MS in Immunology, Cell/Molecular Biology, or related field.
•  At least 2+ years of relevant experience in immunology, I/O, or cancer biology.
•  Experience with cell culture techniques, sorting primary human and/or animal T cells, and developing cell-based immuno-assays and T cell functional assays.
•  Applied expertise in T cell therapeutics is a plus, especially in industry.

Formal descriptions can be supplied for interested candidates.

Must be authorized to work in the U.S. indefinitely to be considered.

All resumes will be kept strictly confidential until you choose to pursue a specific opportunity with one of our clients.

CAR-T Scientist Direct Hire MA

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Job ID: 15301 Direct Hire MA

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Our client is a highly-regarded cell/gene therapy company in the greater Boston area and they are seeking an experienced, highly-motivated Immuno-Oncology Scientist to join their research and discovery team to work on next-generation CAR-T therapies in oncology! You will collaborate with and help other teammates troubleshoot assays, as well as identify and develop new targets and chimeric antigen receptors (CARs). The main function of this role is to develop cell-based assays for T cell characterization, proliferation, and function, and to coordinate new research projects to overcome various obstacles within the tumor microenvironment.

Responsibilities:
•  Design/execute diverse immuno-assays to evaluate T-cell biology, including cell sorting (fluorescent and/or magnetic), multi-color flow cytometry, Luminex, cytokine profiling, etc.
•  Analyze experimental data and present internally to identify promising new CAR candidates for subsequent development.
•  Work collaboratively and cross-functionally for preclinical development in animal models of cancer.

Requirements:
•  PhD in Immunology, Cell/Molecular Biology, or related field.
•  1-5 years of relevant experience in immunology, I/O, or autoimmunity.
•  Experience with cell culture techniques, sorting primary human and/or animal T cells, and developing cell-based immuno-assays and T cell functional assays.
•  Applied expertise in T cell therapeutics is a plus, either in academia or industry.
 

Formal descriptions can be supplied for interested candidates.

Must be authorized to work in the U.S. indefinitely to be considered.

All resumes will be kept strictly confidential until you choose to pursue a specific opportunity with one of our clients.